Chondroitin
Balances the inflammatory system
- Brand:
- CS b-Bioactive®
- Source:
- Spain
- Manufacturer:
- Bioiberica
What is it?
Chondroitin is a naturally occurring sugar found in cartilage.
What does it do?
Chondroitin is what gives your dog’s cartilage the soft, spongy texture it needs to cushion and protect their joints.
Why we chose it
It plays an integral role in repairing cartilage tissue while also blocking the enzymes that cause it to degrade in the first place.
Why not a generic chondroitin?
Our chondroitin is the most extensively researched on the market with over 40 clinical studies behind it.
Evidence
Key Findings
Adults with knee osteoarthritis showed significantly* less pain after taking CS-b Bioactive® for 3 months, compared to the placebo group.
- Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study
- Möller, I.et al (2010). Osteoarthritis and Cartilage, 18, pp. S32–S40
- Participants
- 129 humans aged 40+ years, with knee osteoarthritis
- Length
- 12 weeks
- Type
- Placebo-controlled, Double-blind, Randomized
Further Research
- Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the Chondroitin versus Celecoxib versus Placebo Trial (CONCEPT)
- Reginster, J.-Y. et al (2017). Ann Rheum Dis, 76(9), pp. 1537–1543.
- Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. A randomized, double-blind, placebo-controlled functional magnetic resonance imaging study
- Monfort, J. et al (2017). Medicina Clínica (English Edition), 148(12), pp. 539–547.
- Effect of chondroitin sulphate on synovitis of knee osteoarthritic patients
- Tío, L. et al (2017). Medicina Clínica (English Edition), 149(1), pp. 9–16.
- Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study
- Pelletier, J.-P. et al (2016). Arthritis Res Ther, 18(1).
- Discrepancies in Composition and Biological Effects of Different Formulations of Chondroitin Sulfate
- Martel-Pelletier, J. et al (2015). Molecules, 20(3), pp. 4277–4289.
- Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis
- Provenza, J. R. et al (2015). Clin Rheumatol, 34(8), pp. 1455–1462.
- Randomized, double-blind, multicenter, non inferiority clinical trial with combined glucosamine and chondroitin sulfate vs celecoxib for painful knee osteoarthritis
- Hochberg, M. C. et al (2014). Osteoarthritis and Cartilage, 22, p. S25.
- Equivalence of a single dose (1200 mg) compared to a three-time a day dose (400 mg) of chondroitin 4&6 sulfate in patients with knee osteoarthritis. Results of a randomized double blind placebo controlled study
- Zegels, B. et al (2013). Osteoarthritis and Cartilage, 21(1), pp. 22–27.
- Total Knee Replacement as a Knee Osteoarthritis Outcome
- Raynauld, J.-P. et al (2013). Cartilage, 4(3), pp. 219–226.
- Pharmacoproteomic Study of Three Different Chondroitin Sulfate Compounds on Intracellular and Extracellular Human Chondrocyte Proteomes*.
- Calamia, V. et al (2012). Mol Cell Proteomics, 11(6), p. M111.013417.
- Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI
- Wildi, L. M. et al (2011). Ann Rheum Dis, 70(6), pp. 982–989.
- Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: A randomized, double-blind, placebo-controlled clinical trial at a single center
- Gabay, C. et al (2011). Arthritis & Rheumatism, 63(11), pp. 3383–3391.
- Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT
- Sawitzke, A. D. et al (2010). Annals of the Rheumatic Diseases, 69(8), pp. 1459–1464.
- Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study
- Möller, I. et al (2010). Osteoarthritis and Cartilage, 18, pp. S32–S40
- Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: The study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial
- Kahan, A. et al (2009). Arthritis Rheum, 60(2), pp. 524–533.
- Erratum to “Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo
- Uebelhart, D. et al (2007). Osteoarthritis and Cartilage, 15(8), p. 979.
- Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis.
- Clegg, D. O. et al (2006). N Engl J Med, 354(8), pp. 795–808.
- Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trial
- Michel, B. A. et al (2005). Arthritis Rheum, 52(3), pp. 779–786.
- Systems to Assess the Progression of Finger Joint Osteoarthritis and the Effects of Disease Modifying Osteoarthritis Drugs
- Verbruggen, G. et al (2002). Clin Rheumatol, 21(3), pp. 231–243.
- Efficacy of a combination of FCHG49TM glucosamine hydrochloride, TRH122TM low molecular weight sodium chondroitin sulfate and manganese ascorbate* in the management of knee osteoarthritis
- Das, A. et al (2000). Osteoarthritis and Cartilage, 8(5), pp. 343–350.